منابع مشابه
Physiochemical property of opioids and spinal analgesia
It has been more than two decades since neuraxial opioids first underwent rigorous clinical study for use in humans. The intraspinal route of administration is now commonly used to administer anesthetics and analgesics. Addition of opioids to intraspinal administered local anesthetic provides an effective and prolonged analgesia. However, the physiochemical properties of opioids may influence t...
متن کاملThe Pharmacology of Spinal Opioids and Ziconotide for the Treatment of Non-Cancer Pain
BACKGROUND Intrathecal drug delivery has undergone a revitalization following a better understanding of this delivery route and its pharmacokinetics. Driven by patient safety and outcomes, clinicians are motivated to rethink the traditional spinal infusion pump patient selection criteria and indications. We review the current understanding of the pharmacology of commonly employed intrathecal ag...
متن کاملPhysiology of Spinal Opioids and its relevance for Pain Management Selection
Widespread medical use of unprocessed opium was a common practice along the centuries until morphine was fi rst discovered in 1804 by Friedrich Sertürner, a German Pharmacist, who fi rst distributed this drug in 1817 [1]. The Romanian surgeon Racoviceanu-Pitesti, who reported his experience using a mixture of cocaine and morphine in 1901, made the fi rst publication concerning the use of opioid...
متن کاملClinical pharmacology of spinal opioids for the treatment of pain: A current update on proper usage
OPEN ACCESS This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact reprin...
متن کاملRecommendations for spinal opioids clinical practice in the management of postoperative pain
Opioids have been considered the strongest option in clinical practice for the treatment of postoperative pain. However, in this setting, the spinal administration of an opioid drug does not always guarantee selective action and segmental analgesia in the spine due to partial reuptake to blood systemic circulation reaching brain receptors. Recent evidence from experimental studies indicates tha...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1999
ISSN: 0003-2409
DOI: 10.1046/j.1365-2044.1999.01186.x